{"result":[{"lastName":"Nolan","clinicalFocus":[],"appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","displayName":"Garry Nolan","firstName":"Garry","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Garry_Nolan","researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level."},{"lastName":"Coutre","clinicalFocus":[{"focus":"Hematology"},{"focus":"Idiopathic Hypereosinophillic Syndrome"},{"focus":"Leukemia"},{"focus":"Leukemia - Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Hematology"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Hematology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Hematology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4695&type=small&showNoImage","displayName":"Steven Coutre","firstName":"Steven","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Steven_Coutre","researchInterest":"My research integrates clinical care of patients with novel treatments for a variety of hematologic disorders.  I see patients with a wide range of problems with a particular focus on chronic lymphocytic leukemia and multiple myeloma.  I provide comprehensive consultative services as well as treatment for both the acute and chronic leukemias as well as non-malignant conditions such as clotting disorders and thrombocytopenia."},{"lastName":"Clarke","clinicalFocus":[{"focus":"Colorectal Cancer"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=7126&type=small&showNoImage","displayName":"Michael F. Clarke, M.D.","firstName":"Michael","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Michael_Clarke","researchInterest":"Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine.  In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory  focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa"},{"lastName":"Arber","clinicalFocus":[{"focus":"Anatomic/Clinical Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor - Med Center Line,Pathology"}],"primaryAppointment":"Professor - Med Center Line,Pathology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=3925&type=small&showNoImage","displayName":"Daniel A. Arber, M.D.","firstName":"Daniel","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Daniel_Arber","researchInterest":"I study molecular genetic and immunophenotypic changes in human hematopoietic neoplasms. These include acute and chronic leukemias, lymphoma, and splenic tumors."},{"lastName":"Francke","clinicalFocus":[{"focus":"Clinical Genetics"},{"focus":"Neurogenetics"}],"appointments":[{"appointment":"Professor,Genetics"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Genetics","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4281&type=small&showNoImage","displayName":"Uta Francke","firstName":"Uta","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Uta_Francke","researchInterest":"Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models: Williams-Beuren syndrome, a heterozygous 1.6 megabase deletion; Rett syndrome, caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Mechanisms of genomic imprinting: Prader Willi syndrome"},{"lastName":"Cleary","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"},{"appointment":"Professor,Pediatrics"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4506&type=small&showNoImage","displayName":"Michael Cleary","firstName":"Michael","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Michael_Cleary","researchInterest":"The role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer."},{"lastName":"Crabtree","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","displayName":"Gerald Crabtree","firstName":"Gerald","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Gerald_Crabtree","researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development."},{"lastName":"Sikic","clinicalFocus":[{"focus":"Medical Oncology"},{"focus":"New Drug Studies"}],"appointments":[{"appointment":"Professor,Medicine - Oncology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4131&type=small&showNoImage","displayName":"Branimir I. Sikic, M. D.","firstName":"Branimir","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Branimir_Sikic","researchInterest":"Research Interests: cancer pharmacology, mechanisms of resistance to anticancer drugs, regulation and function of MDR1 and tubulin genes, clinical trials of modulation of drug resistance, general oncology, Phase I trials of new drugs, gene expression profiling of cancers"},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Boxer","clinicalFocus":[{"focus":"Hematology"},{"focus":"Multiple Myeloma"},{"focus":"Multiple Myeloma - Medical Oncology"},{"focus":"Plasmacytoma"},{"focus":"Plasmacytoma - Hematology"},{"focus":"Plasmacytoma - Medical Oncology"}],"appointments":[{"appointment":"Professor,Medicine - Hematology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Medicine - Hematology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4658&type=small&showNoImage","displayName":"Linda Boxer","firstName":"Linda","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Linda_Boxer","researchInterest":"Regulation of expression of oncogenes in normal and malignant hematologic cells."},{"lastName":"Warnke","clinicalFocus":[{"focus":"Anatomic/Clinical Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=3786&type=small&showNoImage","displayName":"Roger Warnke","firstName":"Roger","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Roger_Warnke","researchInterest":"The research in my laboratory involves the application of monoclonal and polyclonal antibodies and a variety of immunohistochemical methods to study human B-cell, T-cell, accessory cell and related neoplasms."},{"lastName":"Lacayo","clinicalFocus":[{"focus":"Hematology/Oncology/Stem Cell Transplant,  Pediatric"},{"focus":"Oncology (Cancer), Pediatric"},{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Assistant Professor - Med Center Line,Pediatrics - Hematology/Oncology"}],"primaryAppointment":"Assistant Professor - Med Center Line,Pediatrics - Hematology/Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=5921&type=small&showNoImage","displayName":"Norman J. Lacayo, MD","firstName":"Norman","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Norman_Lacayo","researchInterest":"Pediatric Hematology/Oncology, Phase I drug studies for refractory and relapsed leukemia; genomic studies, biologic risk-stratification and treatment of acute myeloid leukemia."},{"lastName":"Brown","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4284&type=small&showNoImage","displayName":"Patrick O. Brown","firstName":"Patrick","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Patrick_Brown","researchInterest":"Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program.  The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer."},{"lastName":"Brunet","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Genetics"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Assistant Professor,Genetics","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=6012&type=small&showNoImage","displayName":"Anne Brunet","firstName":"Anne","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Anne_Brunet","researchInterest":"Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri."},{"lastName":"Link","clinicalFocus":[{"focus":"Hematology/Oncology/Stem Cell Transplant,  Pediatric"},{"focus":"Pediatric Hematology-Oncology"}],"appointments":[{"appointment":"Professor,Pediatrics - Hematology/Oncology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pediatrics - Hematology/Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4631&type=small&showNoImage","displayName":"Michael Link","firstName":"Michael","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Michael_Link","researchInterest":"Hematology/Oncology, treatment of sarcomas of bone and soft tissue, biology of acute lymphoblastic leukemias, treatment of non-Hodgkin's lymphoma and Hodgkin's disease."},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation Biology"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation Biology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato Giaccia","firstName":"Amato","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Amato_Giaccia","researchInterest":"Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells."},{"lastName":"Natkunam","clinicalFocus":[{"focus":"Hematopathology"},{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=5929&type=small&showNoImage","displayName":"Yasodha Natkunam, M.D., Ph.D","firstName":"Yasodha","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Yasodha_Natkunam","researchInterest":"My research interests focus on the identification and characterization of markers of diagnostic and prognostic importance in hematolymphoid neoplasia."},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor (Research),Genetics","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","displayName":"Leonore A. Herzenberg","firstName":"Leonore","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Leonore_Herzenberg","researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays."},{"lastName":"Advani","clinicalFocus":[{"focus":"Burkitt's Lymphoma"},{"focus":"Burkitt's Lymphoma - Hematology"},{"focus":"Burkitt's Lymphoma - Medical Oncology"},{"focus":"Hodgkin's Disease"},{"focus":"Investigational Therapeutics"},{"focus":"Leptommeningeal Disease"},{"focus":"Lymphoma "},{"focus":"Mycosis Fungoides"},{"focus":"Non-Hodgkin's Lymphoma"},{"focus":"Oncology"},{"focus":"Oncology (Cancer)"},{"focus":"Plasmacytoma"},{"focus":"Waldenstrom's Macroglobulinemia "}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Oncology"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4018&type=small&showNoImage","displayName":"Ranjana Advani","firstName":"Ranjana","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Ranjana_Advani","researchInterest":"Clinical investigation in Hodgkin's disease, non-Hodgkin's Lymphomas and cutaneous lymphomas.  Experimental therapeutics with novel chemotherapy and biologically targeted therapies.\r\n\r\nThe research program is highly collaborative with radiation oncology, industry, pathology and dermatology."},{"lastName":"Berg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Biochemistry"},{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"primaryAppointment":"Emeritus (Active) Professor,Biochemistry","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=6263&type=small&showNoImage","displayName":"Paul Berg","firstName":"Paul","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Paul_Berg","researchInterest":"For about 10 years until 2000, my lab\u0092s research activities were focused on the mechanism of recombinational repair of double-strand breaks in DNA. We focused our efforts on two model systems:  one involved the repair of restriction enzyme cleavages at specific mammalian chromosomal loci and the second explored the biochemical properties of purified yeast Rad51 protein, an essential catalyst for synapsing the broken ends of DNA with an intact homologue of that sequence.  We also explored the ro"},{"lastName":"Herzenberg","clinicalFocus":[],"appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus (Active) Professor,Genetics","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","displayName":"Leonard Herzenberg","firstName":"Leonard","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Leonard_Herzenberg","researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC)."},{"lastName":"Weissman","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology - Stem Cell Institute"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor (By courtesy),Biology (School of Humanities and Sciences)"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Professor,Pathology - Stem Cell Institute","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4605&type=small&showNoImage","displayName":"Irving Weissman","firstName":"Irving","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Irving_Weissman","researchInterest":"Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis."},{"lastName":"Glader","clinicalFocus":[{"focus":"Pediatric Hematology-Oncology"},{"focus":"Ped Hematology/Oncology"}],"appointments":[{"appointment":"Professor,Pediatrics - Hematology/Oncology"},{"appointment":"Professor (By courtesy),Pathology"}],"primaryAppointment":"Professor,Pediatrics - Hematology/Oncology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=4534&type=small&showNoImage","displayName":"Bertil Glader","firstName":"Bertil","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Bertil_Glader","researchInterest":"Hematology/Oncology, biology, and treatment of bone marrow failure disorders, hereditary coagulation disorders-clinical trials."},{"lastName":"Amylon","clinicalFocus":[{"focus":"Pediatric Hematology-Oncology"},{"focus":"Ped Hematology/Oncology"}],"appointments":[{"appointment":"Emeritus (Active) Professor,Pediatrics - Stem Cell Transplantation"}],"primaryAppointment":"Emeritus (Active) Professor,Pediatrics - Stem Cell Transplantation","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=6097&type=small&showNoImage","displayName":"Michael Amylon","firstName":"Michael","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Michael_Amylon","researchInterest":"Bone marrow transplantation (BMT) is a treatment modality which is being broadly applied to a growing number of disorders. Increasing success with BMT is offering improved survival to pediatric and adult patients with acute leukemia, chronic leukemia, lymphomas, and a variety of solid tumors as well as severe aplastic anemia."},{"lastName":"Chang","clinicalFocus":[{"focus":"Dermatology"}],"appointments":[{"appointment":"Associate Professor,Dermatology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"primaryAppointment":"Associate Professor,Dermatology","imageUrl":"http://ludwigcenter.stanford.edu/profiles/viewImage?facultyId=6089&type=small&showNoImage","displayName":"Howard Y. Chang","firstName":"Howard","href":"http://ludwigcenter.stanford.edu/profiles/cancer/researcher/Howard_Chang","researchInterest":"The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis."}]}