Irving Weissman

Publications

• Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation. Xie X, Chan KS, Cao F, Huang M, Li Z, Lee A, Weissman IL, Wu JC. Stem Cells Dev. 2009; 18 (2): 205-14
• Hematopoietic stem and progenitor cells and the inflammatory response. Jaiswal S, Weissman IL. Ann N Y Acad Sci. 2009: 1174 118-21
• Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Park CY, Tseng D, Weissman IL. Mol Ther. 2009; 17 (2): 219-30
• Endochondral ossification is required for haematopoietic stem-cell niche formation. Chan CK, Chen CC, Luppen CA, Kim JB, DeBoer AT, Wei K, Helms JA, Kuo CJ, Kraft DL, Weissman IL. Nature. 2009; 457 (7228): 490-4
• The adhesion molecule esam1 is a novel hematopoietic stem cell marker. Ooi AG, Karsunky H, Majeti R, Butz S, Vestweber D, Ishida T, Quertermous T, Weissman IL, Forsberg EC. Stem Cells. 2009; 27 (3): 653-61
• Two-step oligoclonal development of male germ cells. Ueno H, Turnbull BB, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (1): 175-80
• Association of reactive oxygen species levels and radioresistance in cancer stem cells. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF. Nature. 2009; 458 (7239): 780-3
• Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Majeti R, Becker MW, Tian Q, Lee TL, Yan X, Liu R, Chiang JH, Hood L, Clarke MF, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (9): 3396-401
• Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capecchi MR, Kuo CJ. Nat Med. 2009; 15 (6): 701-6
• Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Wu AR, Hiatt JB, Lu R, Attema JL, Lobo NA, Weissman IL, Clarke MF, Quake SR. Lab Chip. 2009; 9 (10): 1365-70
• Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development. Yamane T, Hosen N, Yamazaki H, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (22): 8953-8
• Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability. Yamada M, Gurney PT, Chung J, Kundu P, Drukker M, Smith AK, Weissman IL, Nishimura D, Robbins RC, Yang PC. Magn Reson Med. 2009; 62 (4): 1047-54
• Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150. Papathanasiou P, Attema JL, Karsunky H, Xu J, Smale ST, Weissman IL. Stem Cells. 2009; 27 (10): 2498-508
• A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells. Cheshier SH, Kalani MY, Lim M, Ailles L, Huhn SL, Weissman IL. Neurosurgery. 2009; 65 (2): 237-49; discussion 249-50; quiz N6
• CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, van Rooijen N, Weissman IL. Cell. 2009; 138 (2): 286-99
• CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Jaiswal S, Jamieson CH, Pang WW, Park CY, Chao MP, Majeti R, Traver D, van Rooijen N, Weissman IL. Cell. 2009; 138 (2): 271-85
• Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Proc Natl Acad Sci U S A. 2009; 106 (33): 14016-21
• The ISSCR: who are we and where are we going? Weissman I, Cell Stem Cell. 2009; 5 (2): 151-3
• Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Serwold T, Ehrlich LI, Weissman IL. Blood. 2009; 113 (4): 807-15
• SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H. Mol Biol Cell. 2008; 19 (3): 1210-9
• The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z. Mol Cell Biol. 2008; 28 (1): 282-92
• Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages. Karsunky H, Inlay MA, Serwold T, Bhattacharya D, Weissman IL. Blood. 2008; 111 (12): 5562-70
• Isolation of Human Fetal Liver Progenitors and Their Enhanced Proliferation by Three-Dimensional Coculture with Endothelial Cells. Xiong A, Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT. Tissue Eng Part A. 2008
• Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. Cao YA, Wagers AJ, Karsunky H, Zhao H, Reeves R, Wong RJ, Stevenson DK, Weissman IL, Contag CH. Blood. 2008; 112 (12): 4494-502
• The E. Donnall Thomas lecture: normal and neoplastic stem cells. Weissman IL, Biol Blood Marrow Transplant. 2008; 14 (8): 849-58
• Space-time considerations for hematopoietic stem cell transplantation. Bhattacharya D, Ehrlich LI, Weissman IL. Eur J Immunol. 2008; 38 (8): 2060-7
• Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. Cao F, Wagner RA, Wilson KD, Xie X, Fu JD, Drukker M, Lee A, Li RA, Gambhir SS, Weissman IL, Robbins RC, Wu JC. PLoS One. 2008; 3 (10): e3474
• Identification of the endostyle as a stem cell niche in a colonial chordate. Voskoboynik A, Soen Y, Rinkevich Y, Rosner A, Ueno H, Reshef R, Ishizuka KJ, Palmeri KJ, Moiseeva E, Rinkevich B, Weissman IL. Cell Stem Cell. 2008; 3 (4): 456-64
• Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J. Cell Stem Cell. 2008; 3 (4): 416-28
• The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases. Weissman IL, Shizuru JA. Blood. 2008; 112 (9): 3543-53
• Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. Hendry SL, van der Bogt KE, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G, Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC. J Thorac Cardiovasc Surg. 2008; 136 (4): 1028-1037.e1
• Establishment of a normal hematopoietic and leukemia stem cell hierarchy. Chao MP, Seita J, Weissman IL. Cold Spring Harb Symp Quant Biol. 2008: 73 439-49
• In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Park CY, Majeti R, Weissman IL. Nat Protoc. 2008; 3 (12): 1932-40
• Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells. Xiong A, Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT. Tissue Eng Part A. 2008; 14 (6): 995-1006
• Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture. Bababeygy SR, Cheshier SH, Hou LC, Higgins DM, Weissman IL, Tse VC. Stem Cells Dev. 2008; 17 (1): 11-8
• Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Majeti R, Park CY, Weissman IL. Cell Stem Cell. 2007; 1 (6): 635-45
• The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Cheshier SH, Prohaska SS, Weissman IL. Stem Cells Dev. 2007; 16 (5): 707-17
• B-cell development fails in the absence of the Pbx1 proto-oncogene. Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML. Blood. 2007; 109 (10): 4191-9
• Striving for normality: whole body regeneration through a series of abnormal generations. Voskoboynik A, Simon-Blecher N, Soen Y, Rinkevich B, De Tomaso AW, Ishizuka KJ, Weissman IL. FASEB J. 2007; 21 (7): 1335-44
• Hematopoietic stem cell aging: mechanism and consequence. Rossi DJ, Bryder D, Weissman IL. Exp Gerontol. 2007; 42 (5): 385-90
• Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation. Cao F, Drukker M, Lin S, Sheikh AY, Xie X, Li Z, Connolly AJ, Weissman IL, Wu JC. Cloning Stem Cells. 2007; 9 (1): 107-17
• Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Hosen N, Yamane T, Muijtjens M, Pham K, Clarke MF, Weissman IL. Stem Cells. 2007; 25 (7): 1635-44
• The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis. Hosen N, Shirakata T, Nishida S, Yanagihara M, Tsuboi A, Kawakami M, Oji Y, Oka Y, Okabe M, Tan B, Sugiyama H, Weissman IL. Leukemia. 2007; 21 (8): 1783-91
• CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL. Proc Natl Acad Sci U S A. 2007; 104 (26): 11008-13
• Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Nature. 2007; 447 (7145): 725-9
• Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. Proc Natl Acad Sci U S A. 2007; 104 (30): 12371-6
• Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. Serwold T, Hochedlinger K, Inlay MA, Jaenisch R, Weissman IL. J Immunol. 2007; 179 (2): 928-38
• Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging. Rossi DJ, Seita J, Czechowicz A, Bhattacharya D, Bryder D, Weissman IL. Cell Cycle. 2007; 6 (19): 2371-6
• Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation. Bhattacharya D, Cheah MT, Franco CB, Hosen N, Pin CL, Sha WC, Weissman IL. J Immunol. 2007; 179 (10): 6808-19
• Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Czechowicz A, Kraft D, Weissman IL, Bhattacharya D. Science. 2007; 318 (5854): 1296-9
• Cancer stem cells in solid tumors. Ailles LE, Weissman IL. Curr Opin Biotechnol. 2007; 18 (5): 460-6
• Generation of a monoclonal antibody library against human embryonic stem cells. Drukker M, Muscat C, Weissman IL. Methods Mol Biol. 2007: 407 63-81
• Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. Bhattacharya D, Rossi DJ, Bryder D, Weissman IL. J Exp Med. 2006; 203 (1): 73-85
• Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells. Wagers AJ, Weissman IL. Stem Cells. 2006; 24 (4): 1087-94
• In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC. Circulation. 2006; 113 (7): 1005-14
• Pten, tumorigenesis, and stem cell self-renewal. Rossi DJ, Weissman IL. Cell. 2006; 125 (2): 229-31
• Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors. Bhattacharya D, Bryder D, Rossi DJ, Weissman IL. Cell Cycle. 2006; 5 (11): 1135-9
• Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Bryder D, Rossi DJ, Weissman IL. Am J Pathol. 2006; 169 (2): 338-46
• Hematopoietic stem cells: expression profiling and beyond. Forsberg EC, Bhattacharya D, Weissman IL. Stem Cell Rev. 2006; 2 (1): 23-30
• fester, A candidate allorecognition receptor from a primitive chordate. Nyholm SV, Passegue E, Ludington WB, Voskoboynik A, Mitchel K, Weissman IL, De Tomaso AW. Immunity. 2006; 25 (1): 163-73
• Flk2+ myeloid progenitors are the main source of Langerhans cells. Mende I, Karsunky H, Weissman IL, Engleman EG, Merad M. Blood. 2006; 107 (4): 1383-90
• Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Santarelli JG, Udani V, Yung YC, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Neurosurgery. 2006; 59 (2): 374-82; discussion 374-82
• Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer Res. 2006; 66 (19): 9339-44
• Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands. Ueno H, Weissman IL. Dev Cell. 2006; 11 (4): 519-33
• The cancer stem cell hypothesis: a work in progress. Tan BT, Park CY, Ailles LE, Weissman IL. Lab Invest. 2006; 86 (12): 1203-7
• New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. Cell. 2006; 126 (2): 415-26
• Hematopoietic cells maintain hematopoietic fates upon entering the brain. Massengale M, Wagers AJ, Vogel H, Weissman IL. J Exp Med. 2005; 201 (10): 1579-89
• Frizzled 9 knock-out mice have abnormal B-cell development. Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U. Blood. 2005; 105 (6): 2487-94
• Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal. Yamane T, Dylla SJ, Muijtjens M, Weissman IL. Proc Natl Acad Sci U S A. 2005; 102 (9): 3312-7
• Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Nature. 2005; 433 (7027): 760-4
• Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors. Karsunky H, Merad M, Mende I, Manz MG, Engleman EG, Weissman IL. Exp Hematol. 2005; 33 (2): 173-81
• Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Shizuru JA, Negrin RS, Weissman IL. Annu Rev Med. 2005: 56 509-38
• They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response. Kofidis T, deBruin JL, Tanaka M, Zwierzchoniewska M, Weissman I, Fedoseyeva E, Haverich A, Robbins RC. Eur J Cardiothorac Surg. 2005; 28 (3): 461-6
• Cell intrinsic alterations underlie hematopoietic stem cell aging. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ, Weissman IL. Proc Natl Acad Sci U S A. 2005; 102 (26): 9194-9
• Identification of mast cell progenitors in adult mice. Chen CC, Grimbaldeston MA, Tsai M, Weissman IL, Galli SJ. Proc Natl Acad Sci U S A. 2005; 102 (32): 11408-13
• Normal and neoplastic stem cells. Weissman IL, Novartis Found Symp. 2005: 265 35-50; discussion 50-4, 92-7
• Differential expression of novel potential regulators in hematopoietic stem cells. Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL. PLoS Genet. 2005; 1 (3): e28
• Stem cell research: paths to cancer therapies and regenerative medicine. Weissman I, JAMA. 2005; 294 (11): 1359-66
• Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Laird DJ, Chang WT, Weissman IL, Lauzon RJ. Dev Dyn. 2005; 234 (4): 997-1005
• Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. Passegué E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. J Exp Med. 2005; 202 (11): 1599-611
• Isolation and characterization of a protochordate histocompatibility locus. De Tomaso AW, Nyholm SV, Palmeri KJ, Ishizuka KJ, Ludington WB, Mitchel K, Weissman IL. Nature. 2005; 438 (7067): 454-9
• Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis. Udani VM, Santarelli JG, Yung YC, Wagers AJ, Cheshier SH, Weissman IL, Tse V. Stem Cells Dev. 2005; 14 (5): 478-86
• Identification of phenotypic neural stem cells in a pediatric astroblastoma. Huhn SL, Yung Y, Cheshier S, Harsh G, Ailles L, Weissman I, Vogel H, Tse V. J Neurosurg. 2005; 103 (5 Suppl): 446-50
• Stem cells are units of natural selection in a colonial ascidian. Laird DJ, De Tomaso AW, Weissman IL. Cell. 2005; 123 (7): 1351-60
• Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain. Santarelli JG, Udani V, Yung CY, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Clin Neurosurg. 2005: 52 384-8
• Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus. García-Ojeda ME, Dejbakhsh-Jones S, Chatterjea-Matthes D, Mukhopadhyay A, BitMansour A, Weissman IL, Brown JM, Strober S. J Immunol. 2005; 175 (7): 4363-73
• Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury. Kofidis T, de Bruin JL, Yamane T, Tanaka M, Lebl DR, Swijnenburg RJ, Weissman IL, Robbins RC. Circulation. 2005; 111 (19): 2486-93
• Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor. Yung YC, Cheshier S, Santarelli JG, Huang Z, Wagers A, Weissman I, Tse V. Microcirculation. 2004; 11 (8): 699-708
• Continuous development precludes radioprotection in a colonial ascidian. Laird DJ, Weissman IL. Dev Comp Immunol. 2004; 28 (3): 201-9
• Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells. Sherwood RI, Christensen JL, Weissman IL, Wagers AJ. Stem Cells. 2004; 22 (7): 1292-304
• Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration. Kofidis T, de Bruin JL, Yamane T, Balsam LB, Lebl DR, Swijnenburg RJ, Tanaka M, Weissman IL, Robbins RC. Stem Cells. 2004; 22 (7): 1239-45
• Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ. Cell. 2004; 119 (4): 543-54
• JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Passegué E, Wagner EF, Weissman IL. Cell. 2004; 119 (3): 431-43
• Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Laird DJ, Weissman IL. Dev Biol. 2004; 273 (2): 185-94
• Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL. N Engl J Med. 2004; 351 (7): 657-67
• Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Kelly S, Bliss TM, Shah AK, Sun GH, Ma M, Foo WC, Masel J, Yenari MA, Weissman IL, Uchida N, Palmer T, Steinberg GK. Proc Natl Acad Sci U S A. 2004; 101 (32): 11839-44
• Varicella-zoster virus infection of human neural cells in vivo. Baiker A, Fabel K, Cozzio A, Zerboni L, Fabel K, Sommer M, Uchida N, He D, Weissman I, Arvin AM. Proc Natl Acad Sci U S A. 2004; 101 (29): 10792-7
• Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Merad M, Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA, Charo I, Cook DN, Weissman IL, Strober S, Engleman EG. Nat Med. 2004; 10 (5): 510-7
• Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. So CW, Karsunky H, Wong P, Weissman IL, Cleary ML. Blood. 2004; 103 (8): 3192-9
• Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Nature. 2004; 428 (6983): 668-73
• Circulation and chemotaxis of fetal hematopoietic stem cells. Christensen JL, Wright DE, Wagers AJ, Weissman IL. PLoS Biol. 2004; 2 (3): E75
• Plasticity of adult stem cells. Wagers AJ, Weissman IL. Cell. 2004; 116 (5): 639-48
• Evolution of a protochordate allorecognition locus. De Tomaso AW, Weissman IL. Science. 2004; 303 (5660): 977
• Shifting foci of hematopoiesis during reconstitution from single stem cells. Cao YA, Wagers AJ, Beilhack A, Dusich J, Bachmann MH, Negrin RS, Weissman IL, Contag CH. Proc Natl Acad Sci U S A. 2004; 101 (1): 221-6
• Chronic versus acute myelogenous leukemia: a question of self-renewal. Jamieson CH, Weissman IL, Passegué E. Cancer Cell. 2004; 6 (6): 531-3
• Construction and characterization of large-insert genomic libraries (BAC and fosmid) from the Ascidian Botryllus schlosseri and initial physical mapping of a histocompatibility locus. de Tomaso AW, Weissman IL. Mar Biotechnol (NY). 2003 Mar-Apr; 5 (2): 103-15
• Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Cozzio A, Passegué E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Genes Dev. 2003; 17 (24): 3029-35
• Initial characterization of a protochordate histocompatibility locus. De Tomaso AW, Weissman IL. Immunogenetics. 2003; 55 (7): 480-90
• Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Passegué E, Jamieson CH, Ailles LE, Weissman IL. Proc Natl Acad Sci U S A. 2003: 100 Suppl 1 11842-9
• Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Jaiswal S, Traver D, Miyamoto T, Akashi K, Lagasse E, Weissman IL. Proc Natl Acad Sci U S A. 2003; 100 (17): 10002-7
• Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. Karsunky H, Merad M, Cozzio A, Weissman IL, Manz MG. J Exp Med. 2003; 198 (2): 305-13
• Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice. Chatterjea-Matthes D, García-Ojeda ME, Dejbakhsh-Jones S, Jerabek L, Manz MG, Weissman IL, Strober S. J Immunol. 2003; 171 (3): 1207-15
• Wnt proteins are lipid-modified and can act as stem cell growth factors. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R. Nature. 2003; 423 (6938): 448-52
• Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Blood. 2003; 102 (2): 517-20
• Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation. Arber C, BitMansour A, Sparer TE, Higgins JP, Mocarski ES, Weissman IL, Shizuru JA, Brown JM. Blood. 2003; 102 (2): 421-8
• Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Terskikh AV, Miyamoto T, Chang C, Diatchenko L, Weissman IL. Blood. 2003; 102 (1): 94-101
• MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. So CW, Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML. Cancer Cell. 2003; 3 (2): 161-71
• Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice. Beilhack GF, Scheffold YC, Weissman IL, Taylor C, Jerabek L, Burge MJ, Masek MA, Shizuru JA. Diabetes. 2003; 52 (1): 59-68
• Characterization of mouse clonogenic megakaryocyte progenitors. Nakorn TN, Miyamoto T, Weissman IL. Proc Natl Acad Sci U S A. 2003; 100 (1): 205-10
• Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. BitMansour A, Burns SM, Traver D, Akashi K, Contag CH, Weissman IL, Brown JM. Blood. 2002; 100 (13): 4660-7
• Developmental plasticity of lymphoid progenitors. Prohaska SS, Scherer DC, Weissman IL, Kondo M. Semin Immunol. 2002; 14 (6): 377-84
• Prospective isolation of human clonogenic common myeloid progenitors. Manz MG, Miyamoto T, Akashi K, Weissman IL. Proc Natl Acad Sci U S A. 2002; 99 (18): 11872-7
• The road ended up at stem cells. Weissman IL, Immunol Rev. 2002: 185 159-74
• Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Miyamoto T, Iwasaki H, Reizis B, Ye M, Graf T, Weissman IL, Akashi K. Dev Cell. 2002; 3 (1): 137-47
• Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. Allsopp RC, Cheshier S, Weissman IL. J Exp Med. 2002; 196 (11): 1427-33
• Changes in integrin expression are associated with altered homing properties of Lin(-/lo)Thy1.1(lo)Sca-1(+)c-kit(+) hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte colony-stimulating factor. Wagers AJ, Allsopp RC, Weissman IL. Exp Hematol. 2002; 30 (2): 176-85
• Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling. King AG, Kondo M, Scherer DC, Weissman IL. Proc Natl Acad Sci U S A. 2002; 99 (7): 4508-13
• Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. J Exp Med. 2002; 195 (9): 1145-54
• Stem cells--scientific, medical, and political issues. Weissman IL, N Engl J Med. 2002; 346 (20): 1576-9
• Cell fate determination from stem cells. Wagers AJ, Christensen JL, Weissman IL. Gene Ther. 2002; 9 (10): 606-12
• Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role? Allsopp RC, Weissman IL. Oncogene. 2002; 21 (21): 3270-3
• Myeloerythroid-restricted progenitors are sufficient to confer radioprotection and provide the majority of day 8 CFU-S. Na Nakorn T, Traver D, Weissman IL, Akashi K. J Clin Invest. 2002; 109 (12): 1579-85
• Langerhans cells renew in the skin throughout life under steady-state conditions. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I, Weissman IL, Cyster JG, Engleman EG. Nat Immunol. 2002; 3 (12): 1135-41
• Little evidence for developmental plasticity of adult hematopoietic stem cells. Wagers AJ, Sherwood RI, Christensen JL, Weissman IL. Science. 2002; 297 (5590): 2256-9
• Immunity to infections following hematopoietic cell transplantation. Brown JM, Weissman IL, Shizuru JA. Curr Opin Immunol. 2001; 13 (4): 451-7
• Lymphocyte development from hematopoietic stem cells. Kondo M, Scherer DC, King AG, Manz MG, Weissman IL. Curr Opin Genet Dev. 2001; 11 (5): 520-6
• Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Weissman IL, Anderson DJ, Gage F. Annu Rev Cell Dev Biol. 2001: 17 387-403
• Stem cells, cancer, and cancer stem cells. Reya T, Morrison SJ, Clarke MF, Weissman IL. Nature. 2001; 414 (6859): 105-11
• Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Christensen JL, Weissman IL. Proc Natl Acad Sci U S A. 2001; 98 (25): 14541-6
• Physiological migration of hematopoietic stem and progenitor cells. Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL. Science. 2001; 294 (5548): 1933-6
• Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL. Blood. 2001; 98 (3): 627-35
• Dendritic cell development from common myeloid progenitors. Manz MG, Traver D, Akashi K, Merad M, Miyamoto T, Engleman EG, Weissman IL. Ann N Y Acad Sci. 2001: 938 167-73; discussion 173-4
• From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. Proc Natl Acad Sci U S A. 2001; 98 (14): 7934-9
• Dendritic cell potentials of early lymphoid and myeloid progenitors. Manz MG, Traver D, Miyamoto T, Weissman IL, Akashi K. Blood. 2001; 97 (11): 3333-41
• Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. Allsopp RC, Cheshier S, Weissman IL. J Exp Med. 2001; 193 (8): 917-24
• Cyclophosphamide/granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Blood. 2001; 97 (8): 2278-85
• L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Qian F, Hanahan D, Weissman IL. Proc Natl Acad Sci U S A. 2001; 98 (7): 3976-81
• The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. DiMartino JF, Selleri L, Traver D, Firpo MT, Rhee J, Warnke R, O'Gorman S, Weissman IL, Cleary ML. Blood. 2001; 98 (3): 618-26
• Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer. Negrin RS, Atkinson K, Leemhuis T, Hanania E, Juttner C, Tierney K, Hu WW, Johnston LJ, Shizurn JA, Stockerl-Goldstein KE, Blume KG, Weissman IL, Bower S, Baynes R, Dansey R, Karanes C, Peters W, Klein J. Biol Blood Marrow Transplant. 2000; 6 (3): 262-71
• Inactivation of a GFP retrovirus occurs at multiple levels in long-term repopulating stem cells and their differentiated progeny. Klug CA, Cheshier S, Weissman IL. Blood. 2000; 96 (3): 894-901
• Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Shizuru JA, Weissman IL, Kernoff R, Masek M, Scheffold YC. Proc Natl Acad Sci U S A. 2000; 97 (17): 9555-60
• Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, Weissman IL. Nature. 2000; 407 (6802): 383-6
• Function of cytokines in lymphocyte development. Kondo M, Weissman IL. Curr Top Microbiol Immunol. 2000: 251 59-65
• "Fluorescent timer": protein that changes color with time. Terskikh A, Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P. Science. 2000; 290 (5496): 1585-8
• Development of CD8alpha-positive dendritic cells from a common myeloid progenitor. Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman EG, Weissman IL. Science. 2000; 290 (5499): 2152-4
• Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. Domen J, Weissman IL. J Exp Med. 2000; 192 (12): 1707-18
• The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. Domen J, Cheshier SH, Weissman IL. J Exp Med. 2000; 191 (2): 253-64
• Stem cells: units of development, units of regeneration, and units in evolution. Weissman IL, Cell. 2000; 100 (1): 157-68
• Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Weissman IL, Science. 2000; 287 (5457): 1442-6
• Lymphoid precursors. Akashi K, Reya T, Dalma-Weiszhausz D, Weissman IL. Curr Opin Immunol. 2000; 12 (2): 144-50
• A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Akashi K, Traver D, Miyamoto T, Weissman IL. Nature. 2000; 404 (6774): 193-7
• AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Miyamoto T, Weissman IL, Akashi K. Proc Natl Acad Sci U S A. 2000; 97 (13): 7521-6
• 50 million years of chordate evolution: seeking the origins of adaptive immunity. Laird DJ, De Tomaso AW, Cooper MD, Weissman IL. Proc Natl Acad Sci U S A. 2000; 97 (13): 6924-6
• B lymphopoiesis in the thymus. Akashi K, Richie LI, Miyamoto T, Carr WH, Weissman IL. J Immunol. 2000; 164 (10): 5221-6
• Allorecognition in colonial tunicates: protection against predatory cell lineages? Magor BG, De Tomaso A, Rinkevich B, Weissman IL. Immunol Rev. 1999: 167 69-79
• Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate. Domen J, Weissman IL. Mol Med Today. 1999; 5 (5): 201-8
• Lymphoid development from hematopoietic stem cells. Akashi K, Traver D, Kondo M, Weissman IL. Int J Hematol. 1999; 69 (4): 217-26
• Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates. Stoner DS, Rinkevich B, Weissman IL. Proc Natl Acad Sci U S A. 1999; 96 (16): 9148-53
• CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Gandy KL, Domen J, Aguila H, Weissman IL. Immunity. 1999; 11 (5): 579-90
• Lymphoid development from stem cells and the common lymphocyte progenitors. Akashi K, Kondo M, Cheshier S, Shizuru J, Gandy K, Domen J, Mebius R, Traver D, Weissman IL. Cold Spring Harb Symp Quant Biol. 1999: 64 1-12
• In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Cheshier SH, Morrison SJ, Liao X, Weissman IL. Proc Natl Acad Sci U S A. 1999; 96 (6): 3120-5
• Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo. Trahey M, Weissman IL. Proc Natl Acad Sci U S A. 1999; 96 (6): 3006-11
• Mapping the genome of a model protochordate. I. A low resolution genetic map encompassing the fusion/histocompatibility (Fu/HC) locus of Botryllus schlosseri. De Tomaso AW, Saito Y, Ishizuka KJ, Palmeri KJ, Weissman IL. Genetics. 1998; 149 (1): 277-87
• An alternate pathway for T cell development supported by the bone marrow microenvironment: recapitulation of thymic maturation. García-Ojeda ME, Dejbakhsh-Jones S, Weissman IL, Strober S. J Exp Med. 1998; 187 (11): 1813-23
• Linkage analysis of HSP70 genes and historecognition locus in botryllus schlosseri. Fagan MB, Weissman IL. Immunogenetics. 1998; 47 (6): 468-76
• Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Traver D, Akashi K, Weissman IL, Lagasse E. Immunity. 1998; 9 (1): 47-57
• Characterization of a polymorphic protein localized to vascular epithelium in Botryllus schlosseri: role in tunic synthesis? Fagan MB, Weissman IL. Mol Mar Biol Biotechnol. 1998; 7 (3): 204-13
• Role of interleukin-7 in T-cell development from hematopoietic stem cells. Akashi K, Kondo M, Weissman IL. Immunol Rev. 1998: 165 13-28
• Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Domen J, Gandy KL, Weissman IL. Blood. 1998; 91 (7): 2272-82
• Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Proc Natl Acad Sci U S A. 1998; 95 (2): 657-62
• Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population? Randall TD, Weissman IL. Stem Cells. 1998; 16 (1): 38-48
• Tolerance of allogeneic heart grafts in mice simultaneously reconstituted with purified allogeneic hematopoietic stem cells. Gandy KL, Weissman IL. Transplantation. 1998; 65 (3): 295-304
• Two distinct pathways of positive selection for thymocytes. Akashi K, Kondo M, Weissman IL. Proc Natl Acad Sci U S A. 1998; 95 (5): 2486-91
• HSP70 genes and historecognition in Botryllus schlosseri: implications for MHC evolution. Fagan MB, Weissman IL. Hereditas. 1997; 127 (1-2): 25-35
• Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Kondo M, Weissman IL, Akashi K. Cell. 1997; 91 (5): 661-72
• Highly polymorphic microsatellite loci in the colonial ascidian Botryllus schlosseri. Stoner DS, Quattro JM, Weissman IL. Mol Mar Biol Biotechnol. 1997; 6 (3): 163-71
• Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Kondo M, Akashi K, Domen J, Sugamura K, Weissman IL. Immunity. 1997; 7 (1): 155-62
• Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization. Morrison SJ, Wright DE, Weissman IL. Proc Natl Acad Sci U S A. 1997; 94 (5): 1908-13
• Identification of a lineage of multipotent hematopoietic progenitors. Morrison SJ, Wandycz AM, Hemmati HD, Wright DE, Weissman IL. Development. 1997; 124 (10): 1929-39
• Phenotypic and functional changes induced at the clonal level in hematopoietic stem cells after 5-fluorouracil treatment. Randall TD, Weissman IL. Blood. 1997; 89 (10): 3596-606
• From stem cells to lymphocytes: biology and transplantation. Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL. Immunol Rev. 1997: 157 13-40
• Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Lagasse E, Weissman IL. Cell. 1997; 89 (7): 1021-31
• Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL. Cell. 1997; 89 (7): 1033-41
• Somatic and germ cell parasitism in a colonial ascidian: possible role for a highly polymorphic allorecognition system. Stoner DS, Weissman IL. Proc Natl Acad Sci U S A. 1996; 93 (26): 15254-9
• Flow cytometric identification of murine neutrophils and monocytes. Lagasse E, Weissman IL. J Immunol Methods. 1996; 197 (1-2): 139-50
• A developmental switch in lymphocyte homing receptor and endothelial vascular addressin expression regulates lymphocyte homing and permits CD4+ CD3- cells to colonize lymph nodes. Mebius RE, Streeter PR, Michie S, Butcher EC, Weissman IL. Proc Natl Acad Sci U S A. 1996; 93 (20): 11019-24
• Telomerase activity in hematopoietic cells is associated with self-renewal potential. Morrison SJ, Prowse KR, Ho P, Weissman IL. Immunity. 1996; 5 (3): 207-16
• The aging of hematopoietic stem cells. Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. Nat Med. 1996; 2 (9): 1011-6
• The c-kit+ maturation pathway in mouse thymic T cell development: lineages and selection. Akashi K, Weissman IL. Immunity. 1996; 5 (2): 147-61
• Activation of physiological cell death mechanisms by a necrosis-causing agent. Vaux DL, Whitney D, Weissman IL. Microsc Res Tech. 1996; 34 (3): 259-66
• Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Randall TD, Lund FE, Howard MC, Weissman IL. Blood. 1996; 87 (10): 4057-67
• Searching for hematopoietic stem cells. II. The heterogeneity of Thy-1.1(lo)Lin(-/lo)Sca-1+ mouse hematopoietic stem cells separated by counterflow centrifugal elutriation. Uchida N, Jerabek L, Weissman IL. Exp Hematol. 1996; 24 (5): 649-59
• From thymic lineages back to hematopoietic stem cells, sometimes using homing receptors. Weissman IL, J Immunol. 1996; 156 (6): 2019-25
• Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells. Aguila HL, Weissman IL. Blood. 1996; 87 (4): 1225-31
• Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment. Shizuru JA, Jerabek L, Edwards CT, Weissman IL. Biol Blood Marrow Transplant. 1996; 2 (1): 3-14
• Sequence and characterization of two HSP70 genes in the colonial protochordate Botryllus schlosseri. Fagan MB, Weissman IL. Immunogenetics. 1996; 44 (2): 134-42
• Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine-induced CD3+ CD56+ killer cells. Mehta BA, Schmidt-Wolf IG, Weissman IL, Negrin RS. Blood. 1995; 86 (9): 3493-9
• The biology of hematopoietic stem cells. Morrison SJ, Uchida N, Weissman IL. Annu Rev Cell Dev Biol. 1995: 11 35-71
• Heterogeneity of hematopoietic stem cells: implications for clinical applications. Morrison SJ, Weissman IL. Proc Assoc Am Physicians. 1995; 107 (2): 187-94
• Life histories and senescence of Botryllus schlosseri (Chordata, Ascidiacea) in Monterey Bay. Chadwick-Furman NE, Weissman IL. Biol Bull. 1995; 189 (1): 36-41
• Extrathymic maturation of alpha beta T cells from hemopoietic stem cells. Dejbakhsh-Jones S, Jerabek L, Weissman IL, Strober S. J Immunol. 1995; 155 (7): 3338-44
• Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells. Aguila HL, Hershberger RJ, Weissman IL. Proc Natl Acad Sci U S A. 1995; 92 (22): 10192-6
• The purification and characterization of fetal liver hematopoietic stem cells. Morrison SJ, Hemmati HD, Wandycz AM, Weissman IL. Proc Natl Acad Sci U S A. 1995; 92 (22): 10302-6
• Expression of granzyme A in salivary gland biopsies from patients with primary Sjögren's syndrome. Alpert S, Kang HI, Weissman I, Fox RI. Arthritis Rheum. 1994; 37 (7): 1046-54
• Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells. Uchida N, Aguila HL, Fleming WH, Jerabek L, Weissman IL. Blood. 1994; 83 (12): 3758-79
• Demonstration that Thy(lo) subsets of mouse bone marrow that express high levels of lineage markers are not significant hematopoietic progenitors. Morrison SJ, Lagasse E, Weissman IL. Blood. 1994; 83 (12): 3480-90
• An analysis of the expression of cyclophilin C reveals tissue restriction and an intriguing pattern in the mouse kidney. Friedman J, Weissman I, Friedman J, Alpert S. Am J Pathol. 1994; 144 (6): 1247-56
• Regulation of the avidity of integrin alpha 4 beta 7 by the beta 7 cytoplasmic domain. Crowe DT, Chiu H, Fong S, Weissman IL. J Biol Chem. 1994; 269 (20): 14411-8
• Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Qian F, Vaux DL, Weissman IL. Cell. 1994; 77 (3): 335-47
• The isolation of putative major histocompatibility complex gene fragments from dogfish and nurse shark. Bartl S, Weissman IL. Ann N Y Acad Sci. 1994: 712 346-9
• In vitro development of B cells and macrophages from early mouse fetal thymocytes. Péault B, Khazaal I, Weissman IL. Eur J Immunol. 1994; 24 (3): 781-4
• bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. Lagasse E, Weissman IL. J Exp Med. 1994; 179 (3): 1047-52
• Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T-cell receptor V beta gene products. Sen-Majumdar A, Weissman IL, Hansteen G, Marian J, Waller EK, Lieberman M. J Virol. 1994; 68 (2): 1165-72
• Infection and multiple sclerosis: a possible role for superantigens? Brocke S, Veromaa T, Weissman IL, Gijbels K, Steinman L. Trends Microbiol. 1994; 2 (7): 250-4
• Characterization of preneoplastic thymocytes and of their neoplastic progression in irradiated C57BL/Ka mice. Sen-Majumdar A, Guidos C, Kina T, Lieberman M, Weissman IL. J Immunol. 1994; 153 (4): 1581-92
• Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells. Weissman IL, Immunity. 1994; 1 (7): 529-31
• The common gamma (gamma c) chain for multiple cytokine receptors. Weissman IL, Jpn J Cancer Res. 1994; 85 (10): inside front cover
• The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Morrison SJ, Weissman IL. Immunity. 1994; 1 (8): 661-73
• PCR primers containing an inosine triplet to complement a variable codon within a conserved protein-coding region. Bartl S, Weissman IL. Biotechniques. 1994; 16 (2): 246-8, 250
• Developmental switches in the immune system. Weissman IL, Cell. 1994; 76 (2): 207-18
• Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark. Bartl S, Weissman IL. Proc Natl Acad Sci U S A. 1994; 91 (1): 262-6
• A colonial invertebrate species that displays a hierarchy of allorecognition responses I.L. Weissman, Rinkevich, G., Y. Saito,. Biological Bulletin. 1993 184
• The whole body view. Weissman IL, Curr Biol. 1993; 3 (11): 766-9
• The Peyer's patch homing receptor. Hu MC, Holzmann B, Crowe DT, Neuhaus H, Weissman IL. Curr Top Microbiol Immunol. 1993: 184 125-38
• The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats. Chen RH, Ivens KW, Alpert S, Billingham ME, Fathman CG, Flavin TF, Shizuru JA, Starnes VA, Weissman IL, Griffiths GM. Transplantation. 1993; 55 (1): 146-53
• Heterogeneity of hematopoietic stem cells. Uchida N, Fleming WH, Alpern EJ, Weissman IL. Curr Opin Immunol. 1993; 5 (2): 177-84
• Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Fleming WH, Alpern EJ, Uchida N, Ikuta K, Weissman IL. Proc Natl Acad Sci U S A. 1993; 90 (8): 3760-4
• LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Su L, Hershberger RJ, Weissman IL. Genes Dev. 1993; 7 (5): 735-48
• Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. Waller EK, Ziemianska M, Bangs CD, Cleary M, Weissman I, Kamel OW. Blood. 1993; 82 (1): 247-61
• Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate. Kraft DL, Weissman IL, Waller EK. J Exp Med. 1993; 178 (1): 265-77
• Cloning and characterization of cyclophilin C-associated protein: a candidate natural cellular ligand for cyclophilin C. Friedman J, Trahey M, Weissman I. Proc Natl Acad Sci U S A. 1993; 90 (14): 6815-9
• Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC. Cell. 1993; 74 (1): 185-95
• Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. Fleming WH, Alpern EJ, Uchida N, Ikuta K, Spangrude GJ, Weissman IL. J Cell Biol. 1993; 122 (4): 897-902
• How the immune system develops. Weissman IL, Cooper MD. Sci Am. 1993; 269 (3): 64-71
• Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2. Vaux DL, Weissman IL. Mol Cell Biol. 1993; 13 (11): 7000-5
• Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells. Schmidt-Wolf IG, Lefterova P, Mehta BA, Fernandez LP, Huhn D, Blume KG, Weissman IL, Negrin RS. Exp Hematol. 1993; 21 (13): 1673-9
• Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Vaux DL, Weissman IL, Kim SK. Science. 1992; 258 (5090): 1955-7
• Human T-cell development in SCID-hu mice: staphylococcal enterotoxins induce specific clonal deletions, proliferation, and anergy. Waller EK, Sen-Majumdar A, Kamel OW, Hansteen GA, Schick MR, Weissman IL. Blood. 1992; 80 (12): 3144-56
• Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis. Griffiths GM, Alpert S, Lambert E, McGuire J, Weissman IL. Proc Natl Acad Sci U S A. 1992; 89 (2): 549-53
• Characterization of several classes of mouse hematopoietic progenitor cells. Heimfeld S, Weissman IL. Curr Top Microbiol Immunol. 1992: 177 95-105
• Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. Uchida N, Weissman IL. J Exp Med. 1992; 175 (1): 175-84
• Lymphocyte homing receptors. Hu MC, Siegelman MH, Holzmann B, Crowe DT, Weissman IL. Cold Spring Harb Symp Quant Biol. 1992: 57 291-308
• Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Ikuta K, Weissman IL. Proc Natl Acad Sci U S A. 1992; 89 (4): 1502-6
• Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Lagasse E, Weissman IL. Blood. 1992; 79 (8): 1907-15
• Development of gamma delta T-cell subsets from fetal hematopoietic stem cells. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. Ann N Y Acad Sci. 1992: 651 21-32
• Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing. Vaux DL, Aguila HL, Weissman IL. Int Immunol. 1992; 4 (7): 821-4
• Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis. Lieberman M, Hansteen GA, Waller EK, Weissman IL, Sen-Majumdar A. J Exp Med. 1992; 176 (2): 399-405
• Genomic organization of the mouse granzyme A gene. Two mRNAs encode the same mature granzyme A with different leader peptides. Hershberger RJ, Gershenfeld HK, Weissman IL, Su L. J Biol Chem. 1992; 267 (35): 25488-93
• Clonal analysis of hematopoietic stem-cell differentiation in vivo. Smith LG, Weissman IL, Heimfeld S. Proc Natl Acad Sci U S A. 1991; 88 (7): 2788-92
• Granzyme A and perforin as markers for rejection in cardiac transplantation. Griffiths GM, Namikawa R, Mueller C, Liu CC, Young JD, Billingham M, Weissman I. Eur J Immunol. 1991; 21 (3): 687-93
• Identification of a 107-kD glycoprotein that mediates adhesion between stromal cells and hematolymphoid cells. Kina T, Majumdar AS, Heimfeld S, Kaneshima H, Holzmann B, Katsura Y, Weissman IL. J Exp Med. 1991; 173 (2): 373-81
• Growth of primary T-cell non-Hodgkin's lymphomata in SCID-hu mice: requirement for a human lymphoid microenvironment. Waller EK, Kamel OW, Cleary ML, Majumdar AS, Schick MR, Lieberman M, Weissman IL. Blood. 1991; 78 (10): 2650-65
• Development of mouse hematopoietic lineages. Heimfeld S, Weissman IL. Curr Top Dev Biol. 1991: 25 155-75
• The junctional modifications of a T cell receptor gamma chain are determined at the level of thymic precursors. Ikuta K, Weissman IL. J Exp Med. 1991; 174 (5): 1279-82
• Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor. Ikuta K, Ingolia DE, Friedman J, Heimfeld S, Weissman IL. Int J Cell Cloning. 1991; 9 (5): 451-60
• Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Friedman J, Weissman I. Cell. 1991; 66 (4): 799-806
• Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL. J Exp Med. 1991; 174 (1): 139-49
• Cloning and expression of cDNAs for the alpha subunit of the murine lymphocyte-Peyer's patch adhesion molecule. Neuhaus H, Hu MC, Hemler ME, Takada Y, Holzmann B, Weissman IL. J Cell Biol. 1991; 115 (4): 1149-58
• The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding. Siegelman MH, Cheng IC, Weissman IL, Wakeland EK. Cell. 1990; 61 (4): 611-22
• B cell infiltration of the thymic medulla in New Zealand black, New Zealand white, and (New Zealand black x New Zealand white)F1 mice. Effect of total lymphoid irradiation. Fariñas MC, Adkins B, Stall AM, Weissman I, Strober S. Arthritis Rheum. 1990; 33 (5): 702-10
• Characterization of a rat monoclonal antibody specific for a determinant encoded by the V beta 7 gene segment. Depletion of V beta 7+ T cells in mice with Mls-1a haplotype. Okada CY, Holzmann B, Guidos C, Palmer E, Weissman IL. J Immunol. 1990; 144 (9): 3473-7
• Allorecognition histocompatibility in a protochordate species: is the relationship to MHC somatic or structural? Weissman IL, Saito Y, Rinkevich B. Immunol Rev. 1990: 113 227-41
• An immunodominant murine lymphoma cell surface heterodimer marks thymic progenitor subsets. Majumdar AS, Guidos C, Kaneshima H, White JH, Marian J, Lieberman M, Weissman IL. J Immunol. 1990; 144 (1): 111-21
• Structural similarity between a primitive chordate membrane heterodimer and lymphocyte antigen receptors. Danska JS, McIntyre BW, McDevitt HO, Weissman IL. Int Immunol. 1990; 2 (9): 795-802
• The growth factor IL-7 induces expression of a transformation-associated antigen in normal pre-B cells. Sherwood PJ, Weissman IL. Int Immunol. 1990; 2 (5): 399-406
• A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. Cell. 1990; 62 (5): 863-74
• Biosynthesis pathway of gp90MEL-14, the mouse lymph node-specific homing receptor. van de Rijn M, Weissman IL, Siegelman M. J Immunol. 1990; 145 (5): 1477-82
• T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. Guidos CJ, Danska JS, Fathman CG, Weissman IL. J Exp Med. 1990; 172 (3): 835-45
• Some observation on the life history of lymphocytes. Weissman IL, Harvey Lect. 1989-1990: 85 43-69
• Intrathymic maturation of murine T lymphocytes from CD8+ precursors. Guidos CJ, Weissman IL, Adkins B. Proc Natl Acad Sci U S A. 1989; 86 (19): 7542-6
• Integrin molecules involved in lymphocyte homing to Peyer's patches. Holzmann B, Weissman IL. Immunol Rev. 1989: 108 45-61
• Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues. Okada CY, Weissman IL. J Exp Med. 1989; 169 (5): 1703-19
• Identification of a novel bone marrow-derived B-cell progenitor population that coexpresses B220 and Thy-1 and is highly enriched for Abelson leukemia virus targets. Tidmarsh GF, Heimfeld S, Whitlock CA, Weissman IL, Müller-Sieburg CE. Mol Cell Biol. 1989; 9 (6): 2665-71
• Role of interleukin-4 in T-cell ontogeny: changes in cell surface phenotype and lymphokine production of immature thymocytes after culture with interleukin-4 and phorbol ester. Guidos C, Ransom J, Fischer M, Weissman I, Zlotnik A. J Autoimmun. 1989: 2 Suppl 141-53
• Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. van de Rijn M, Heimfeld S, Spangrude GJ, Weissman IL. Proc Natl Acad Sci U S A. 1989; 86 (12): 4634-8
• Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. Holzmann B, Weissman IL. EMBO J. 1989; 8 (6): 1735-41
• Developmental potential of CD4-8- thymocytes. Peripheral progeny include mature CD4-8- T cells bearing alpha beta T cell receptor. Guidos CJ, Weissman IL, Adkins B. J Immunol. 1989; 142 (11): 3773-80
• Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. Siegelman MH, Weissman IL. Proc Natl Acad Sci U S A. 1989; 86 (14): 5562-6
• Measurement of binding specificity between T cell lymphomas and murine leukemia viruses. O'Neill HC, Weissman IL. J Immunol Methods. 1989; 122 (1): 79-90
• Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Holzmann B, McIntyre BW, Weissman IL. Cell. 1989; 56 (1): 37-46
• Developmental analysis of the mouse hematolymphoid system. Heimfeld S, Guidos CJ, Holzmann B, Siegelman MH, Weissman IL. Cold Spring Harb Symp Quant Biol. 1989: 54 Pt 1 75-85
• Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow. Spangrude GJ, Klein J, Heimfeld S, Aihara Y, Weissman IL. J Immunol. 1989; 142 (2): 425-30
• Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains. Siegelman MH, van de Rijn M, Weissman IL. Science. 1989; 243 (4895): 1165-72
• Approaches to an understanding of pathogenetic mechanisms in AIDS. Weissman I, Rev Infect Dis. 1988 Mar-Apr; 10 (2): 385-98
• Expression of two serine esterase genes during an allograft rejection in the mouse. Mueller C, Gershenfeld HK, Lobe CG, Okada CY, Bleackley RC, Weissman IL. Transplant Proc. 1988; 20 (2): 251-3
• Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. McCune JM, Rabin LB, Feinberg MB, Lieberman M, Kosek JC, Reyes GR, Weissman IL. Cell. 1988; 53 (1): 55-67
• Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus. Spangrude GJ, Muller-Sieburg CE, Heimfeld S, Weissman IL. J Exp Med. 1988; 167 (5): 1671-83
• Total lymphoid irradiation leads to transient depletion of the mouse thymic medulla and persistent abnormalities among medullary stromal cells. Adkins B, Gandour D, Strober S, Weissman I. J Immunol. 1988; 140 (10): 3373-9
• Molecular tools for inactivating a yeast enzyme in vivo. Carlson JR, Weissman IL. Mol Cell Biol. 1988; 8 (6): 2647-50
• Purification and characterization of mouse hematopoietic stem cells. Spangrude GJ, Heimfeld S, Weissman IL. Science. 1988; 241 (4861): 58-62
• Was the MHC made for the immune system, or did immunity take advantage of an ancient polymorphic gene family encoding cell surface interaction molecules? A speculative essay. Weissman IL, Int Rev Immunol. 1988; 3 (4): 397-416
• Autoreactive blood cells and programmed cell death in growth and development of protochordates. Harp JA, Tsuchida CB, Weissman IL, Scofield VL. J Exp Zool. 1988; 247 (3): 257-62
• The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL. Science. 1988; 241 (4873): 1632-9
• In situ localization of HuHF serine protease mRNA and cytotoxic cell-associated antigens in human dermatoses. A novel method for the detection of cytotoxic cells in human tissues. Wood GS, Mueller C, Warnke RA, Weissman IL. Am J Pathol. 1988; 133 (2): 218-25
• The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets. Spangrude GJ, Aihara Y, Weissman IL, Klein J. J Immunol. 1988; 141 (11): 3697-707
• Infection of the SCID-hu mouse by HIV-1. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM. Science. 1988; 242 (4886): 1684-6
• Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous. Spangrude GJ, Weissman IL. J Immunol. 1988; 141 (6): 1877-90
• A T cell- and natural killer cell-specific, trypsin-like serine protease. Implications of a cytolytic cascade. Gershenfeld HK, Hershberger RJ, Mueller C, Weissman IL. Ann N Y Acad Sci. 1988: 532 367-79
• Homing receptors and metastasis. Sher BT, Bargatze R, Holzmann B, Gallatin WM, Matthews D, Wu N, Picker L, Butcher EC, Weissman IL. Adv Cancer Res. 1988: 51 361-90
• Normal thymic cortical epithelial cells developmentally regulate the expression of a B-lineage transformation-associated antigen. Adkins B, Tidmarsh GF, Weissman IL. Immunogenetics. 1988; 27 (3): 180-6
• Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease. Gershenfeld HK, Hershberger RJ, Shows TB, Weissman IL. Proc Natl Acad Sci U S A. 1988; 85 (4): 1184-8
• A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor. Mueller C, Gershenfeld HK, Lobe CG, Okada CY, Bleackley RC, Weissman IL. J Exp Med. 1988; 167 (3): 1124-36
• Molecules recognized by anti-idiotypic monoclonal antibodies to the B cell lymphoma, BCL1. Tamura GS, McGrath MS, Weissman IL. J Mol Cell Immunol. 1987; 3 (4): 243-53
• The phenotype of thymocytes derived from a single clonogenic precursor. Ezine S, Jerabek L, Weissman I. J Immunol. 1987; 139 (7): 2195-9
• High endothelial venule binding as a predictor of the dissemination of passaged murine lymphomas. Bargatze RF, Wu NW, Weissman IL, Butcher EC. J Exp Med. 1987; 166 (4): 1125-31
• Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. Lieberman M, Hansteen GA, McCune JM, Scott ML, White JH, Weissman IL. J Exp Med. 1987; 166 (6): 1883-93
• The in vivo behavior of T cell clones: altered migration due to loss of the lymphocyte surface homing receptor. Dailey MO, Gallatin WM, Weissman IL. J Mol Cell Immunol. 1985; 2 (1): 27-36
• Immunoglobulin gene rearrangement during pre-B cell differentiation. Coffman RL, Weissman IL. J Mol Cell Immunol. 1983; 1 (1): 31-41